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    ?'???D??o?????????e?a50-500g/mlo250-2000g/ml???a????D??????o????DNA???e????D???o????D?????????150o500mg/kg?iv????AUC?????????????2.8?10?????D??????????50mg/kg??AUC?????????????????T'????Ames3????????????????500?5000g/ml?????????T???????

    ?3??D??o'?D?D??2??????????90 mg/kg/???AUC?????????????????a5mg/kg????????????1.7??????y?e????DD?a????y|?????2????????????????t??2???????????a0.2-lOmg/kg???y?eD?D?D?y|??????2????D?o1?????|??2??????????????D?'|??????????AUC???a?????2??????AUC??0.03-0.1???

    ???????2???????????oD?????D?????D???2?????D??????????????e?a60mg/kg/?o108mg/kg/???????2?AUC???????85??????oD?3???????????????1?2??????o???33?o?????????????o/??????D?????????o?|????T????D???D?????D????1?y2????o????????y??o?????D????1?2?????/?????D?o???????

    '?D?D??????????D?o???????2????90mg/kg???y?e'?1?????D?D?????o'?oo????y2???????????????2???????AUC??????D?????????????AUC??1.7???

    ?????oD??-????????????a20o1000mg/kg/???D??????AUC???????e????2?????????5mg/kg/???0.1o1.4?????????a1000mg/kg/??????????D?D?D?????D?D?o'?D?D???????D??3?????'?D?D??3?????32??1?????????o????????????????????a20mg/kg/????????D?D?D???o????D?D?o'?D?D??????o'?D?D?????????????D?t??????????a1mg/kg/???AUC??????????????0.01??????'1?2????????3y???????????a?????????y?e???????a????a1?'D??????D???????????????o??????D?|????2???????|????????????????????????

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    ??2?????5mg/kg??????1D?????AUC???22.1?3.2?n=16??o26.8?6.1|g?h/ml??????Cmax???8.27?1.02?n=16??o9.0?1.4|g /ml?n=16????

    3??D|?o20yHIV??D??????8D?걷t????a1000mg?????????t???oo?D602???o46.5???????3??????AUC??22?22?????-6???68????????a????????Tmax???????3??'1.8?0.8????3.0?0.6D???Cmax???(0.85?0.25?0.96?0.27|g /ml)?n=20????

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